Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro
نویسندگان
چکیده
منابع مشابه
The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias
Tefinostat (CHR-2845) is a novel monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor which is cleaved into its active acid by the intracellular esterase human carboxylesterase-1 (hCE-1). The in vitro efficacy of tefinostat was characterised in cell lines and in a cohort of 73 primary AML and CMML samples. Dose-dependent induction of apoptosis and significant growth inhibitory effe...
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ژورنال
عنوان ژورنال: Cancer Nanotechnology
سال: 2020
ISSN: 1868-6958,1868-6966
DOI: 10.1186/s12645-020-00070-8